San Francisco 49ers vs Denver Broncos prediction and betting tips (September 25)
Both sides head into this game after grabbing their first win of the season. However, the 49ers will look to make it two wins in a row as they face the Broncos in Week 3 of the 2022/2023 NFL season.
With 18 carries for 84 yards, Jeff Wilson led the 49ers' running backs in their last outing.
With 18 carries for 84 yards, Jeff Wilson led the 49ers' running backs in their last outing.

A two-game win streak is possible as the San Francisco 49ers prepare to play the Denver Broncos in Week 3 of the season. The 49ers turned things around for themselves in Week 2 against Russell Wilson’s former team, the Seattle Seahawks. The 49ers had lost their game against the Bears in Week 1. The Broncos got their first win of the season in a 16-9 win over Houston after losing in week one in a sensational game against the Seattle Seahawks.

The match starts at 8:20 p.m. ET on Sunday, 25 September 2022. The game time by GMT is 12:20 a.m. GMT on Monday, September 26. The match venue is Empower Field at Mile High in Denver, Colorado.

Betting tips and match predictions for the San Francisco 49ers vs Denver Broncos (September 25 game are available in this article. In addition, the latest betting odds, key stats, team news, and projected starting lineups are previewed below.

San Francisco 49ers vs Denver Broncos latest odds on betting sites

The San Francisco 49ers money line odds are priced at 1.80 (-125 American 4/5 Fractional), while the Denver Broncos money line odds are priced at 2.05 (+105; 21/20). This equals approximate probabilities of 55% against 45%, respectively.


  • Over 44.0 points — 1.90 (-111; 9/10)
  • Under 44.0 points — 1.90 (-111; 9/10)


  • San Francisco 49ers -1.5: 1.90 (-111; 9/10)
  • Denver Broncos +1.5: 1.90 (-111; 9/10)

San Francisco 49ers vs Denver Broncos match preview and statistics

San Francisco 49ers got back to winning ways against the Seattle Seahawks. The scoreline was 27-7 as the 49ers' defence shut down the Seahawks' offence. The Seahawks' only touchdown was a blocked field goal return by Michael Jackson after Tariq Woolen stormed through and blocked Robbie Gould.

Quarterback Jimmy Garoppolo, who came from the bench to replace injured 49ers starting quarterback Trey Lance, completed 13 of 21 throws for 154 yards, one touchdown, and no interceptions against the Seahawks. With 63 yards on five receptions, wide receiver Brandon Aiyuk averaged 12.6 yards per catch. With 18 carries for 84 yards, Jeff Wilson led the 49ers' running backs with 4.7 yards per carrying.

Four hurries and two sacks highlighted the defensive end, Nick Bosa’s outstanding performance, and a QB hit. On 25 snaps, He finished with a season-high pass-rush grade of 90.0. The Niners' offensive line did well to allow nine total pressures on 36 pass-blocking snaps and didn't give up a single sack to the Seahawks.

The San Francisco 49ers team news: George Kittle, Arik Armstead, Daniel Brunskill and Colton McKivitz are questionable for the game, while Tyrion Davis-Price, Elijah Mitchell, Trey Lance and Tyler Kroft are ruled out.

Denver Broncos got their first win of the season in their previous outing last week. When the Broncos played the Texans, they won 16-9 and returned home triumphant. Russell Wilson had one touchdown and completed the game with 219 yards on 14 of 31 passes and a quarterback rating of 66.5. Running back Javonte Williams ran the ball 15 times for 75 yards, averaging 5.0 yards per run for the Denver Broncos.

For the Broncos, wide receiver Courtland Sutton was a prominent target, catching seven passes for 122 yards, 17.4 yards per catch. Kicker Brandon McManus made all three of his field goal attempts. McManus has made six of seven field goal attempts so far this year.

However, the offensive line for Denver played the entire game admirably. They only allowed six pressures overall as a pass-blocking team, and no lineman permitted more than one in the contest.

The Denver Broncos team news: Jerry Jeudy, Josey Jewell, Pat Surtain II, KJ Hamler, Dre’Mont Jones, D.J. Jones and Tyrie Cleveland are questionable, while Tom Compton and Justin Simmons are out for the game.

San Francisco 49ers vs Denver Broncos H2H

The two teams have met each other 15 times, including one postseason game, with the Denver Broncos winning seven games and the San Francisco 49ers winning eight games. Their last encounter was in 2018 when Broncos emerged victors in a 20-14 win over the 49ers.

San Francisco 49ers vs Denver Broncos lineups and key players

San Francisco 49ers projected lineup:

  • Quarterback — Jimmy Garoppolo
  • Running back — Jeff Wilson Jr.
  • Wide receiver — Deebo Samuel, Brandon Aiyuk, Jauan Jennings
  • Tight end — George Kittle
  • Offensive line — Kyle Juszczyk, Trent Williams, Aaron Banks, Jake Brendel, Spencer Burford, Mike McGlinchey
  • Defensive line — Samson Ebukam, Javon Kinlaw, Arik Armstead, Nick Bosa
  • Linebacker — Dre Greenlaw, Fred Warner, Azeez Al-Shaair
  • Cornerback — Emmanuel Moseley, Charvarius Ward
  • Safety — Talanoa Hufanga, Tashaun Gipson Sr.
  • Kicker — Robbie Gould
  • Punter — Mitch Wishnowsky

Jeff Wilson Jr. is the key player to watch out for. The 49ers have found success running with the ball, and Jeff Wilson Jr is key to that. With 18 carries for 84 yards, Jeff Wilson led the 49ers' running backs in their last outing.

Denver Broncos projected lineup:

  • Quarterback — Russell Wilson
  • Running back — Javonte Williams
  • Wide receiver — Courtland Sutton, Jerry Jeudy, KJ Hamler
  • Tight end — Albert Okwuegbunam
  • Offensive line — Andrew Beck, Garett Bolles, Dalton Risner, Lloyd Cushenberry III, Quinn Meinerz, Billy Turner
  • Defensive line — Dre’Mont Jones, D.J. Jones, DeShawn Williams
  • Linebacker — Randy Gregory, Alex Singleton, Josey Jewell, Bradley Chubb
  • Cornerback — Pat Surtain II, Ronald Darby
  • Safety — Kareem Jackson, Caden Sterns
  • Kicker — Brandon McManus
  • Punter — Corliss Waitman

Russell Wilson is the key player to watch out for. If he keeps getting protected by the offensive line, he will flourish. The Broncos have given Wilson time in the pocket. He's added 559 yards on the season in the air.

San Francisco 49ers vs Denver Broncos predictions and betting tips

The Denver Broncos' first two games had seen them play well. This team, though, just isn't able to take advantage of long drives. Unsuccessful instruction undoubtedly contributed to the situation. However, despite scoring only 16 points per week, this offence averages over 400 yards per game. Russell Wilson is gradually adjusting to life at Denver, but he’d need to drop a masterclass when he faces the 49ers to have a chance at stringing two wins in a row. However, first-half losses of defensive back Patrick Surtain II and wide receiver Jerry Jeudy in their last game against the Texans will impact their game against the 49ers.

The 49ers have seen how good they are running with the ball, and they will be eager to run the ball frequently. Right now, running back Jeff Wilson Jr. is the team's run leader with 27 carries for 106 yards. Especially with Jimmy Garoppolo returning as the starting quarterback, Deebo Samuel might gain some yardage on the ground. The 49ers’ defence has excelled in coverage. They have also only allowed 67.5 yards on the rush. The 49ers should exploit Denver's vulnerability in stopping the run game. I’d back the 49ers to win at the Empower Field.

Predictions for the game are the San Francisco 49ers to win and under 44.0 points.

Betting prediction: San Francisco 49ers to win

Odds: 1.80 (-125 American 4/5 Fractional)

Betting prediction: Under 44.0 points

Odds: 1.90 (-111 American; 9/10 Fractional)

San Francisco 49ers — Denver Broncos
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San Francisco 49ers to win
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